Observation on Preventive Effect of Ca/Mg Infusion Combined with Glutathione and Carbamazepine on Oxaliplatin-induced Neurotoxicity / 中国药房
China Pharmacy
; (12)2001.
Article
de Zh
| WPRIM
| ID: wpr-527696
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE:To observe the preventive effect of Ca/Mg infusion combined with glutathione and carbamazepine on oxaliplatin-induced neurotoxicity.METHODS:65patients treated with oxaliplatin,5-fluorouracil and leucovorin for gas-trointestinal cancer were divided into treatment group undergoing treatment with Ca/Mg infusion combined with glutathione and carbamazepine,and control group without any preventive treatment.RESULTS:At the third cycle,7patients in the treat-ment group but17patients in the control group showed clinically evident neurotoxicity,which demonstrated the statistical difference between the two groups(P=0.036).After12cycles,neurotoxicity of grade2to3was observed in2patients in the treatment group but in9patients in the control group,which demonstrated the statistical difference between the two groups(P=0.022).CONCLUSION:Ca/Mg infusions combined with glutathione and carbamazepine can prevent oxaliplatin-induced neurotoxicity.
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WPRIM
langue:
Zh
Texte intégral:
China Pharmacy
Année:
2001
Type:
Article