HLA-DRB1 genotyping and its relation with chronic HBV infection in patients / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1989.
Article
Dans Chinois
| WPRIM
| ID: wpr-527857
ABSTRACT
AIM:
To study the HLA-DRB1 genotype and their relation with HBV infection in Shaanxi Han patients.METHODS:
HLA-DRB1 genotyping was conducted in 108 case of chronic HBV infection and 108 health controls as well as 32 asymtomatic HBsAg carriers by using polymerase chain reaction-sequence specific primer method.All the patients,asymtomatic HBsAg carriers and health subjects were residents of Shaanxi district and belonged to Han nationality.The association between HLA-DRB1 genotype and different replication of HBV was also studied.RESULTS:
DRB1~*04,DRB1~*09,DRB1~*12 and DRB1~*15 were the most common genotypes in Shaanxi Han residents with the frequency of 16.2%,12.5%,11.6% and 13.4%,respectively.Compared to 108 health controls,the allele frequency of HLA-DRB1~*03(10.6% of HBV patients versus 3.7% of health controls,odds ratio=3.10;P
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Pathophysiology
Année:
1989
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS