Effects of acute HIV-1 infection on gene expression in U937 promonocytes / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1989.
Article
Dans Chinois
| WPRIM
| ID: wpr-528145
ABSTRACT
AIM:
To study the effects of acute HIV-1 infection on gene expression in U937 human promonocyte for understanding the pathogenecis of AIDS.METHODS:
The expression levels of 550 host cell RNA transcripts in U937 human promonocyte at 2-3 d after HIV-1 infection were assessed using cDNA microarray analysis, and the results were confirmed by semiquantitative RT-PCR.RESULTS:
Our results showed that 38 genes were differentially regulated in the infected U937 cells at 2-3 d post infection 26 genes were down-regulated and 12 genes were up-regulated. These genes encode a host of proteins with divergent functions in a variety of cellular processes including receptor-mediated signaling transduction, subcellular signal trafficking, apoptosis, transcriptional regulation, and chemotaxis.CONCLUSION:
HIV-1 infection alters gene expression in U937 human promonocytes.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Pathophysiology
Année:
1989
Type:
Article
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