Determination of Etoposide in Children with Leukemia by HPLC / 中国药房
China Pharmacy
; (12)2005.
Article
de Zh
| WPRIM
| ID: wpr-528345
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE: To establish HPLC method for the determination of plasma etoposide level in children with leukemia. METHODS: The determination was performed on column Hypersil ODS. The mobile phase was water-methanol (45∶55) and the wavelength for detection was 284nm. RESULTS: The intraday recovery ranged from 93.56 to 96.24% with SD ranged at 1.07%~2.63%, and the inter-day recovery ranged from 92.85% to 94.26% with SD ranged at 3.55%~5.89%. CONCLUSION: This method is simple and sensitive, showed a good specificity, and suitable for the determination of etoposide in clinic samples.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
China Pharmacy
Année:
2005
Type:
Article