Pharmacodynamic Optimization of Purification Technique for Acanthopanax Senticosus Harms / 中国药房
China Pharmacy
; (12)2001.
Article
Dans Zh
| WPRIM
| ID: wpr-529094
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVE: To optimize the purification technique for the extract of Acanthopanax senticosus Harms. METHODS: The techniques of D- 101 macroporous resin adsorption, polyamide adsorption and n- butanol extraction were separately applied to purify the aqueous extract of Acanthopanax senticosus Harms. Syringin was detected by HPLC and total flavone was detected by UV. The anti- cerebral ischemia effects of three purified samples were compared using rat MCAO model and mouse decapitation gape model. RESULTS: The three purified samples all showed anti- cerebral ischemia effects, with the sample purified via D- 101 macroporous resin adsorption having stronger effects than the other two. The content of Syringin was correlated with anti- cerebral ischemia effects. CONCLUSIONS: D- 101 macroporous resin adsorption is a be-tter technique for purifying the aqueous extract of Acanthopanax senticosus Harms.
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WPRIM
langue:
Zh
Texte intégral:
China Pharmacy
Année:
2001
Type:
Article