Preparation and Quality Control of Breviscapine Orally Disintegrating Tablet / 中国药房

ABSTRACT

OBJICTIVE To prepare Breviscapine orally disintegrating tablet and to establish its quality control method. METHODS: The formula of the core of the tablet was optimized with disintegration time as a parameter by an orthogonal design, and the content and the related substances of Breviscapine orally disintegrating tablet were determined by HPLC. RESULTS: The prepared Breviscapine orally disintegrating tablet showed a good stability, and its characters, dissolution, content and the related substances were all in conformity with the related specifications stated in Chinese Pharmacopoeia (2005 edition). CONCLUSION: The methods of preparation and Quality control are simple and feasible.