Determination of Dolasetron Mesylate by HPLC / 中国药房
China Pharmacy
;
(12)2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-529319
ABSTRACT
OBJECTIVE:
To establish a HPLC method for the determination of dolastron mesylate.METHODS:
The sample was separated on Diamonsil C18 column.The mobile phase consisted of acetonitrile-water-1mol? L-1 ammonium formate(450∶ 440∶ 110)(pH=8.0 adjusted with trithylamine)with a flow rate of 1.0mL? min-1.The UV detection wavelength was set at 285nm and the sample size was 20? L.RESULTS:
The linear range of dolasetron mesylate was 24~ 56? g? min-1(r=0.999 6),with average recovery at 99.7%(RSD=0.74%).CONCLUSION:
The established is simple,sensitive and reproducible,and suitable for the quality control of dolasetron mesylate.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
China Pharmacy
Année:
2005
Type:
Article
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