Ulinastatin Administered by Different Routes for Severe Acute Pancreatitis in Rats / 中国药房
China Pharmacy
;
(12)2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-529708
ABSTRACT
OBJECTIVE:
To study the curative effect and mechanism of ulinastatin (UTI) administered by two different routes for severe acute pancreatitis (SAP).METHODS:
50 healthy male SD rats were randomly divided into 5 groups sham operation (SO) group (fed with water ad libitum), SAP model group, positive control(nafamostat) group, ulinastatin peripheral venous perfusion group, and ulinastatin celiac arterial perfusion group. SAP model was established in the latter four groups, and then the rats were treated with corresponding drugs. 12h later, sample tissues were taken from pancreas and lungs for measurement of MPO level and histopathologic observation and the blood samples were collected for measurement of serum amylase, TNF-? and TXB2.RESULTS:
Levels of amylase, TNF-?, TXB2, MPO and Hughes histopathologic scores of pancreas and lungs in all drug-treated groups were significantly lower than in SAP group (P
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Étude pronostique
langue:
Chinois
Texte intégral:
China Pharmacy
Année:
2007
Type:
Article
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