Observations on acute rejection reaction of orthotopic liver transplantation in Wistar-SD rats / 中国普通外科杂志

ABSTRACT

Objective To observe the manifestations and judgement methods of acute rejection reaction of orthotopic liver transplantation in Wistar-SD rats.Methods The survival conditions after operation in rats was observed,and liver function tests and histopathology examination were used to study the manifestations of acute rejection reaction of orthotopic liver transplantation in Wistar-SD rats.Results Wistar-SD experiment group had moderate to severe acute rejection reaction after OLT.Alanine aminotransferase,aspartate aminotransferase,total bilirubin io clood serum after orthotopic liver transplantation in rats was obviously elevated on 1-3 d and 7 d after OLT,which are significantly different from every corresponding time point of control group(P