Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease
Experimental & Molecular Medicine
;
: 333-347, 2006.
Article
Dans Anglais
| WPRIM
| ID: wpr-53157
ABSTRACT
Inflammation, a self-defensive reaction against various pathogenic stimuli, may become harmful self-damaging process. Increasing evidence has linked chronic inflammation to a number of neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis. In the central nervous system, microglia, the resident innate immune cells play major role in the inflammatory process. Although they form the first line of defense for the neural parenchyma, uncontrolled activation of microglia may directly toxic to neurons by releasing various substances such as inflammatory cytokines (IL-1beta, TNF-alpha, IL-6), NO, PGE
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Maladie de Parkinson
/
Transduction du signal
/
Cytokines
/
Démence associée au SIDA
/
Microglie
/
Médiateurs de l'inflammation
/
Matrix metalloproteinase 3
/
Metalloproteases
/
Encéphalite
/
Alpha-Synucléine
Type d'étude:
Etude d'étiologie
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Experimental & Molecular Medicine
Année:
2006
Type:
Article
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