Inhibitory Effect of Tea Polyphenols in Combination with Anti-tumor Drugs on Cell Proliferation of the Multiresistant HNE-1 Cell Line / 中国药房
China Pharmacy
;
(12)1991.
Article
Dans Chinois
| WPRIM
| ID: wpr-531649
ABSTRACT
OBJECTIVE:
To study the joint action of tea polyphenols and common anti-tumor drugs(vincristine,pingyangmycin,5-Fu,cisplatin) in inhibiting cell proliferation of the multiresistant HNE-1(200) cell line in patients with nasopharyngeal carcinoma after radiographic exposure.METHODS:
The low toxic dosage of tea polyphenols and 4 kinds of anti-tumor drugs were optimized by MTT method.Then the inhibition ratio of multiresistant HNE-1(200) cell line treated by tea polyphenols and anti-tumor drugs waere detected.RESULTS:
The low toxic dosage of tea polyphenols was 0.50 mg?mL-1.When the anti-tumor drugs were used in combination with tea polyphenols(0.50 mg?mL-1) as compared without,the inhibition ratio on HNE-1(200) cell line was increased by 100%~300%.CONCLUSIONS:
Addition of tea polyphenols to anti-tumor drugs showed remarkable inhibitory effect on cell proliferation of HNE-1(200) cell line in patients with nasopharyngeal carcinoma,suggesting the reverse effect of tea polyphenols on resistant HNE-1(200) cell line.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
China Pharmacy
Année:
1991
Type:
Article
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