Determination of Amphotericin B in Vaginal Effervescent Tablets by RP-HPLC / 中国药房
China Pharmacy
;
(12)2001.
Article
Dans Chinois
| WPRIM
| ID: wpr-531926
ABSTRACT
OBJECTIVE:
To establish a RP-HPLC method for the content determination of amphotericin B in amphotericin B vaginal effervescent tablets.METHODS:
HPLC was performed on Kromasil C18 column with the mobile phase consisted of 0.01 mol ?L-1 potassium dihydrogen-acetonitrile(66∶34) at a flow rate of 1.0 mL?min-1.The detection wavelength was set at 408 nm;the sample size was 10 ?L,and the column temperature was set at room temperature.RESULTS:
The linearity of amphotericin B was good in the range of 0.404~3.636 ?g(r=0.999 4) and the average recovery rate was 99.39%(RSD=0.22%,n=6).CONCLUSIONS:
The method is simple,accurate,feasible,and it can be used for the determination of this tablets.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
China Pharmacy
Année:
2001
Type:
Article
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