Safety of Pretreatment Protocols of Paclitaxel Liposome / 中国药房

ABSTRACT

OBJECTIVE:To evaluate the safety of several pretreatment protocols of paclitaxel liposome as a chemotherapy for upper gastrointestinal tumor.METHODS:26 patients with upper gastrointestinal tumors receiving paclitaxel liposome in combination with other chemotherapeutics were enrolled.The patients were injected intravenously with dexamethasone 10 mg (i ) or dexamethasone 5 mg(ii ) or prednisolone 40 mg(iii ) 30 minutes prior administration of paclitaxel liposome,or treated with oral dexamethasone at a dose of 6 mg(i ),4.5 mg(ii ) or 2.25 mg(iii ) 12 hours or 2 hours prior administration of paclitaxel liposome.RESULTS:Chemotherapy- induced toxic adverse reactions manifested as gradeⅠ～Ⅱleucopenia,anemia, nausea and vomiting,but recovered after symptomatic treatment.Pretreatment- related adverse reactions manifested as insomnia, hyperglycemia,fatigue and vertigo,but no allergic shock or treatment- related death occurred.CONCLUSION:Intravenous injection of prednisolone 40 mg 30 minutes prior administration of paclitaxel liposome or oral administration of dexamethasone 2.25 mg 12 hours and 2 hours prior administration of paclitaxel liposome are preferable pretreatment methods of paclitaxel liposome.