Antibiotic-Associated Diarrhea in COPD Patients:Analysis of 82 Cases / 中国药房

ABSTRACT

OBJECTIVE:To probe into the incidence,latency,clinical features and prevention of the antibiotic-associated diarrhea (AAD). METHODS:968 patients with chronic obstructive pulmonary diseases (COPD) treated with antibiotics in the respiratory department of our hospital were prospectively followed for 30 days immediately after administration of antibiotics. RESULTS:The incidence of AAD was 8.47% (82/968) and the latency of AAD was (8.35?5.19) days. 84.15%(69/82)of the AAD cases manifested as simple diarrhea. The AAD was chiefly induced by cephalosporins (42.68%) and penicillins (23.17%). The incidence of AAD increased markedly if the length of the antibiotic treatment was ≥7 days or if at least 3 kinds of the antibiotics were used concomitantly. After discontinuation or alteration of the antibiotics or administration of microbial ecological agents,metronidazole or vancomycin,71(86.59%) of the total 82 AAD cases were cured,10(12.20%) improved and 1 (1.21%) showed no response. CONCLUSION:AAD is a frequent complication of antibiotic therapy. A powerful measure to prevent AAD is rational use of antibiotics.