Effect of Compound Qinbai Granule for Wound Healing of Radioactive Dermatitis in Rats / 中医杂志

ABSTRACT

Objective To study the mechanism of the Compound Qinbai Granule (Granules composed of Scutellaria root and Phellodendron bark) in the treatment of radioactive dermatitis in rats.Methods The rat models of radioactive dermatitis were established and randomized into three groups:Compound Qinbai Granule group (experimental group),dexamethasone ointment group (traditional group),and normal saline group (control group).The wound was treated with Compound Qinbai Granule spray,dexamethasone ointment external application,and normal saline spray respectively.By immunohistochemical staining and image analysis,the growth of granulation tissue in the wound area wound healing rate,and the expression of basic fibroblast growth factor (bFGF) in the wound tissues were determined on the second,sixth,tenth,eighteenth,and twenty-fourth day after injury.Results The average number of granulation tissue and wound healing rate in the experimental group on the sixth,tenth,eighteenth,and twenty-fourth day were all higher than those in the traditional group and control group with a significant difference (P