Study on the Change of the Content of Ginsenosides in the Decoction of Panax ginseng and Veratrum nigrum / 中国药房

ABSTRACT

OBJECTIVE:To study the change of the content of ginsenosides in the decoction of Panax ginseng and Veratrum nigrum and to find out the change regularity of chemical components in the compatibility of P. ginseng and V. nigrum so as to introduce the mechanism of "P. ginseng and V. nigrum are incompatible with each other" which derives from compatibility theory of Traditional Chinese Medicine. METHODS:HPLC was adopted to determine the content of ginsenoside in decoction derived from the combination of P. ginseng with different amounts of V. nigrum,and colorimetry was applied to determine the content of the total ginsenosides in herbal esidues. RESULTS:The content of the total ginsenosides decreased in the decoction as long as the content of V. nigrum increased. Nevertheless,the content of ginsenosides didn't change as amount of V. nigrum increased. CONCLUSION:It is reasonable to some extent that ginseng and veratrum nigrum are incompatible with each other. With the amount of V. nigrum increasing,the decrease of the total ginsenosides content doesn't result from some components in V. nigrum inhibiting the dissolution of ginsenoside in water solution but result from some components in V. nigrum reacting with ginsenoside leading to the reduction of ginsenoside.