Content Determination of Main Component and Related Substances in Amlodipine Maleate Dispersible Tablets by HPLC / 中国药房
China Pharmacy
;
(12)2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-533941
ABSTRACT
OBJECTIVE:
To established an HPLC method for the determination of main component and related substances in amlodipine maleate dispersible tablets.METHODS:
The separation was performed on a Lichrospher C18 column. The mobile phase consisted of methanol-0.03 mol?L-1 potassium dihydrogen phosphate (70 ∶ 30) at the flow rate of 1 mL?min-1. The detection wavelength was set at 237 nm and column temperature was 30 ℃.RESULTS:
The linear range of amlodipine maleate were 31.94~127.75 ?g?mL-1 (r=0.999 8, n=5). The average recovery was 99.5% (RSD=0.39%, n=9). The contents of related substance were all lower than 0.38%.CONCLUSION:
The method is simple, rapid, accurate and specific for the quality control of amlodipine maleate dispersible tablets.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
China Pharmacy
Année:
2005
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS