Effect of Pingwei Xiaodao Capsule on Gastric Motility of Functional Dyspepsia Model Rats / 中医杂志

ABSTRACT

Objective To observe the effect and mechanism of Pingwei Xiaodao Capsule (Capsule for functional dyspepsia) on the gastric motility of functional dyspepsia (FD) model rats.Methods Totally 60 wistar rats were randomized into a blank control group (normal group),model group,domperidone group,Pingwei Xiaodao Capsule large,medium,and small dosage groups.Except for the normal group,the rats of all other groups were irritated by clamping tails for making FD models.Then,the treatment was given for 7 days.The comparative observation was carried out on the gastric interdigestive myoelectric complex (IMC),slow wave frequency variation coefficient,abnormal rhythm index,and gastric emptying rate of all groups.Results Compared with the model group,the IMC period of domperidone group and all Pingwei Xiaodao Capsule groups was shortened,phase Ⅲ prolonged,incidence of phase Ⅲ increased(P