HYPERLACTACIDEMIA DUE TO PHENFORMIN IN NIDDM / 中华内分泌代谢杂志

ABSTRACT

Having been given Phenformin (DBI) for up to 6 months, 40 cases of NIDDM with normal hepatic and renal functions showed various degrees of hyperlactacidemia. The mean value of hyperlactacidemia increased with ages, but had no relation to the course of disease. Since DBI is liable to cause hyperlactacidemic coma, it is suggested that DBI, if indicated,should be used with great prudence, especially for those senile diabetics with impaired hepatic and renal functions.