EFFECTS OF SELENIUM IN DIET ON RAT PANCREAS PROTEIN SYNTHESIS AND ENZYMES ACTIVITY / 西安交通大学学报(医学版)

ABSTRACT

The study was to investigate comparatively the changes of protein synthesis and amylase, chymotrypsin, lipase activity in pancreas from two groups rats fed with selenium deficient diet from a Keshan disease (KD) endemic area (Se 0.021ppm) and KD diet supplemented with sodium selenite(Se 0.264ppm). The rats fed with Xian's cereals were taken as the control group. The results of our observations suggest that the dietary selenium of 0.241ppm level is sufficient to stimulate inocroporation of [~3H]-Leucine in protein by rat pancreas slices, to increase activity of amylase, chymotrypsin and lipase, toi ncrease activity of GSH-Px and to decrease TBA value in rat pancreas. In addition, it increases body weight and decreases mortality in rats too. It seems that selenium, by the ways of stimulating protein synthesis and increasing activity of pancreasec enzymes, can protect the pancreas and lead to gain weight in rats.