In vivo administration of recombinant IL—6 accelerates the immunological reconstitution of mice following bone marrow transplantation / 中国免疫学杂志

ABSTRACT

In this study the effect of rIL—6 on the immunological reconstitution of mice following bone marrow transplantation(BMT)was evaluated.The lethally irradiated(950Rad)BALB/c mice engrafted with BMT were injected ip with rIL—6(1000 ug/kg)on day 2.At day 30 after BMT the proliferative responses to ConA and LPS,the mixde lymphocyte reaction(MLR)and the activity of cytotoxic T lymphocytes(CTL)to the allogeneic splenic cells(C57BL/6),and the numbers of plaque forming cells(PFC)to SRBC were significantly enhanced in the rIL—6 treated recipient mice,as compared to that in the control BMT mice.In the BMT mice following 10 day rIL—6 treatment,the above immune functions on day30 after BMT were recovered to the immunological condition of the control BMT mice on day 60,suggesting that the rIL—6 is able to accelerate the process of immunological reconstitution of BMT mice.