bcr_3/abl_2 ANTISENSE OLIGODEOXYNUCLEOTIDE INDUCES APOPTOSIS IN CHRONIC MYELOID LEUKEMIA / 中国癌症杂志

ABSTRACT

PURPOSE To investigate the effects of bcr3/abl2 anisense oligodeoxynucleotide (ASO) on chronic myeloid leukemia (CML). METHODS The effects of bcr3/abl2 ASO in 15 CML patients were evaluated by morphological observation, flow cytometer (FCM) techniques and DNA fragment measurement. RESULTS bcr3/abl2 ASO can induce apoptosis in CML. CONCLUSION Antisense techniques may provide a new way to cure CML.