Experimental study of gliosis and synaptic reorganization in the hippocampus of chronic temporal lobe epilepsy rats induced by kainic acid / 中华神经科杂志

ABSTRACT

Objective To investigate the relationship between gliosis, synaptic reorganization and the mechanism of chronic temporal lobe epilepsy induced by kainic acid. Methods The mossy fibers sprouting, synaptic reorganization and gliosis were observed by Neo-Timm staining and immunohistochemical staining respectively. Results The injected (ipslateral) side was injured predominantly in the CA 3 subfield and hilus, whereas the CA 1 subfield was injured mildlyThe contralateral side showed pathological changes mainly in the CA 1 subfield and hilus, and moderately in the CA 3 subfieldThe longer the rats survived, the more obvious changes were observed in the hippocampuses. Conclusion The injection of kainic acid in hippocampus can cause neuronal loss, reactive gliosis and plasticity of neurons, probably form the abnormal neuronal discharge circuit, finally induce the seizures