Neurotensin Involved in Electroacupuncture Analgesia / 第二军医大学学报

ABSTRACT

Experiments were undertaken in rats to investigate the effect of intraventrical injection of neurotensin (NT) and antineurotensin serum (ANTS) on electroacupuncture (EA) analgesia. Neurotensin administration induced a enhancement of pain threshold and increased electroacupuncture analgesia Injection of antineurotensin serum reduced the pain threshold significantly and diminished the effect of electroacupuncture analgesia. Furthermore, pre-injection of naloxone 100?g intraventrically could weaken analgesic effect of NT and NT-EA analgesia. These results indicate that neurotensin in central nervous system is involved in pain modulation and plays a role in EA analgesia The effect of neurotensin may be partly conducted by endogenous opiate peptides.