Expression of TGF ?1 ,TGF ?2 and TGF? receptor Ⅱ in oral squamous cell carcinoma / 实用口腔医学杂志

ABSTRACT

Objective: To determine the relationship of the expression of transforming growth factor ?1(TGF ?1), TGF ?2 and TGF? receptor(T?RⅡ) with the development of squamous cell carcinoma (OSCC). Methods: 40 cases of OSCC and 20 cases of normal oral mucosa were examined with SABC immunohistochemical staining for the expression of TGF ?1, TGF ?2 and T?RⅡ. Results: Semi quantitative analysis revealed that TGF ?1, TGF ?2 and T?RⅡ were expresed in OSCC and normal oral mucosa. TGF ?1, TGF ?2 were overexpressed in OSCC compared with those in normal oral mucosa, while T?RⅡ expression were reduced. Overexpression of TGF ?1, TGF ?2 and reduced expression of T?RⅡ were associated with pathological grade, clinical stage and neck lymph node metastasis( P