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Effect of warfarin on experimental calcium oxalate stone formation in rats / 中华泌尿外科杂志
Chinese Journal of Urology ; (12)2001.
Article Dans Chinois | WPRIM | ID: wpr-538572
ABSTRACT
Objective To investigate the effect of warfarin on the formation of renal calcium oxalate stones induced by 1% ethylence glycol (EG) and 3% ammonium chloride (NH 4Cl) in rats. Methods 30 adult male Wistar rats were randomized to three groups,the control group (A) being non-treated,the stone group (B) rats taken EG and NH 4Cl,and the warfarin group (C) taken warfarin in addition to EG and NH 4Cl.All rats were bred 4 weeks.The renal tissue calcium,the renal calcium oxalate crystallization,and the urinary calcium excretion and serum biochemical data were detected. Results No significant difference has been noted in 3 groups,although there is a tend that number of ranal calcium oxalate crystals in group C was more than that in group B. Conclusions The results denoted that warfarin had no significant effect on the calcium oxalate crystallization in rats.

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Essai clinique contrôlé langue: Chinois Texte intégral: Chinese Journal of Urology Année: 2001 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Essai clinique contrôlé langue: Chinois Texte intégral: Chinese Journal of Urology Année: 2001 Type: Article