Effect of Zhongjiling tablet on IFN-?,IL-4,TGF-? in experimental autoimmune my- asthenia gravis(EAMG) rat / 中国免疫学杂志

ABSTRACT

Objective: To explore cytokine mechanism of Zhongjiling Tablet therapy to experimental autoimmune myasthenia gravis (EAMG). Methods: Lewis rats were immunized with N2-AChR(from Torpedo's electrical organ)in CFA. ELISA were adopted to determine IFN-?,IL-4,TGF-? levels in serum and surpernatant fluids and anti-N2-AChR total IgG,IgG1,IgG2 titers in serum of EAMG on week 7 post immunization and treatment.Results:In serum and surpernatant fluidsIFN-?,IL-4 level in model group were dramatically higher than CEA group ( P