Role of telomere, telomerase and hTERT in colorectal carcinoma / 中国癌症杂志
China Oncology
; (12)1998.
Article
de Zh
| WPRIM
| ID: wpr-541687
Bibliothèque responsable:
WPRO
ABSTRACT
Purpose:To explore the role of terminal restric tion fragments (TRFs), telomerase activity and expression of human telomerase re verse transcriptase (hTERT) in colorectal carcinoma. Methods:The telomere length, telomerase activity and expression of hTERT were studied with Southern-blot, TRAP and immunohistochemistry, respe ctively. Results:TRFs in cancer tissue was much shorter than in the adja cent tissues and normal mucosa, and TRFs was decreased gradually along with the development in cancer stage.The expression of Telomerase in colorectal carcinoma tissue was significantly higher than that in other tissues (P
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
China Oncology
Année:
1998
Type:
Article