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The Effect of Gadd Genes Expression in Surveillance of DNA Damage Induced by Nitrogen Mustard / 环境与健康杂志
Journal of Environment and Health ; (12)1992.
Article Dans Chinois | WPRIM | ID: wpr-541804
ABSTRACT
Objective To study the effect of Gadd genes expression in surveillance of DNA damage. Methods The human liver tumor cells were treated with alkylating agent(nitrogen mustard) and total RNA was extracted, the expression levels of Gadd genes were determined by RT-PCR. Results Treated with 1 ng/?l nitrogen mustard for 3 h, 24 h, 48 h respectively and with 1 ng/?l, 5 ng/?l nitrogen mustard for 24 h respectively, the expression levels of Gadd genes increased at first (P0.05). Conclusion Gadd genes expression can be used as the indexes in the surveillance of DNA damage induced by nitrogen mustard.

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Étude de dépistage langue: Chinois Texte intégral: Journal of Environment and Health Année: 1992 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Étude de dépistage langue: Chinois Texte intégral: Journal of Environment and Health Année: 1992 Type: Article