A Study on Micronuclei and DNA Damage of Bone Marrow Cells of Mice Induced by Holmium Ions of Rare Earths / 环境与健康杂志
Journal of Environment and Health
; (12)1989.
Article
de Zh
| WPRIM
| ID: wpr-542124
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To investigate the genotoxicity of heavy rare-earth holmium to bone-marrow cells of mice.Methods Kunming mice were randomly divided into six groups and were given holmium-trioxide-HCl by gavage at several doses of 0,10,20,40,80 and 160 mg/kg bw respectively one time a day for two days;other Kunming mice were randomly divided into 3 groups and holmium nitrate was given i.p.at doses of 10,40 and 80 mg/kg bw respectively one time a day for two days.24 hours after the last treatment,the bone-marrow cells of thighbone were collected for micronuclei analysis and single cell gel electrophoresis (SCGE).Results Frequencies of micronuclei were increased by the 2 kinds of holmium solutions at the dosage from 10 to 80 mg/kg bw with a dose-effect relationship,but at the dose of 160 mg/kg bw,it was lower than the negative control.In SCGE,the average tail length increased significantly (P
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Journal of Environment and Health
Année:
1989
Type:
Article