Expression and significance of p27 and Ki-67 in breast invasive ductal carcinoma / 肿瘤研究与临床

ABSTRACT

Objective To investigate the correlation of the expression of p27 and Ki-67 with the clinicopathologic features in breast invasive ductal carcinoma. Methods S-P immunohistochemical staining was performed to examine the expression of p27 and Ki-67 in 60 specimens of breast invasive ductal carcinoma. Results The low p27 expression rate was 45.0 %(27/60), low expression in breast cancer was associated with larger tumor, nerve/vessel invasion, lymph node metastasis and histological grade(P