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Effects of roxithromycin on TNF-? and IL-6 release from periodontal ligment fibroblasts stimulated with lipopolysaccharide / 实用口腔医学杂志
Article de Zh | WPRIM | ID: wpr-542446
Bibliothèque responsable: WPRO
ABSTRACT
Objective:To test the effects of roxithromycin(RM) on TNF? and IL-6 release from periodontal ligment fibroblasts(PDLCs) stimulated with lipopolysaccharide(LPS).Methods:PDLCs of passage 4~8 were cultured with RM at 2,20 and 200 ?g/ml respectively with 10 ?g/ml of LPS.The control cells were cultured with culture medium only.The cultures were continued for 3,6,12 and 24 hours respectively.ELISA method was used to measure TNF-? and IL-6 released into the culture medium from PDLCs in the different groups.Results:LPS increased both TNF-? and IL-6 release from PDLCs at all the time points(P
Mots clés
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Journal of Practical Stomatology Année: 2001 Type: Article
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Journal of Practical Stomatology Année: 2001 Type: Article