Tumor necrosis factor-? gene polymorphism is related to thyroid-associated ophthalmopathy / 中华内分泌代谢杂志

ABSTRACT

The -1031T/C polymorphism of tumor necrosis factor-? (TNF-?) gene was determined by PCR-RFLP in 54 patients with thyroid-associated ophthalmorpathy (TAO), 60 patients with autoimmune thyroid disease (AITD) without ophthalmopathy and 76 healthy subjects. The results showed that the frequencies of TC+CC genotype and C allele in TAO group, especially in male patients, were significantly higher than those in the other two groups (both P