A case of levocetirizine-induced liver injury
Clinical and Molecular Hepatology
;
: 495-498, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-54508
ABSTRACT
Levocetirizine is a second-generation nonsedative antihistaminic agent that has been demonstrated to be safe and effective for treating allergic disease. There was only one case report of levocetirizine-induced liver toxicity, but a liver biopsy was not performed. In this article, we present the first case of levocetirizine-induced liver injury with histologic findings. A 48-year-old man was hospitalized with jaundice and generalized pruritus that had developed after 2 months of therapy with levocetirizine for prurigo nodularis. Laboratory findings revealed acute hepatitis with cholestasis. A liver biopsy demonstrated portal inflammation and hepatitis with apoptotic hepatocytes. The patient fully recovered 3 weeks after withdrawing levocetirizine. Although levocetirizine is safe and effective, physicians should be aware of its potential hepatotoxicity.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Prurit
/
Cétirizine
/
Antihistaminiques H1 non sédatifs
/
Lésions hépatiques dues aux substances
/
Hypersensibilité
/
Ictère
/
Foie
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Clinical and Molecular Hepatology
Année:
2016
Type:
Article
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