Combined measurement of serum CYFRA21-1,NSE,CEA,CA19-9,CA125 and SCC:diagnosis value to lung cancer / 中国癌症杂志

ABSTRACT

Background and purpose:Measurement of tumor markers in serum is widely used for the diagnosis of lung cancer, but the positive rates of single marker for diagnosis of lung cancer were not high. This study was to investigate the clinical value of combined measurement of serum CYFRA21-1,NSE,CEA,CA19-9,CA125 for the diagnosis of lung cancer. Methods:The levels of CYFRA21-1,NSE,CEA,CA19-9,CA125,SCC were assayed and compared between the lung cancer group(135 cases) and cancer-free control group(20 case) by electrochemiluminesence immunoassay.Results:The levels of CYFRA21-1,NSE,CEA,CA19-9,CA125 and SCC in the lung cancer group were (7?8) ng/ml,(30?29) ng/ml,(65?293) ng/ml,(110?379) U/ml,(122?412) U/ml and (2?7) ng/ml, respectively, which were higher than those in the control group. The levels of the six tumor markers were associated with pathology of lung cancer, the levels of CEA were (11?25)?10 ng/ml,(2?4) ?10 ng/ml,(2?3)?10 ng/ml in the adenocarcinoma , squamous cell carcinoma and small cell carcinoma cases respectively; the levels of CA125 were (21?48)?10 U/ml,(48?57) ?10 U/ml,(5?4)?10 U/ml in the adenocarcinoma ,squamous cell carcinoma and small cell carcinoma patients, respectively; the levels of CA199 were (17?44) ?10 U/ml,(5?12)?10 U/ml,(4?4) ?10 U/ml in the adenocarcinoma, squamous cell carcinoma and small cell carcinoma patients, respectively. The levels of CEA,CA125,CA19-9 in the adenocarcinoma were higher than those in the squamous cell carcinoma and small cell carcinoma, but there was no significance different(P