Evaluation of EMMPRIN(CD147) expression in cervical cancer:a critical role in development and progression / 中国癌症杂志
China Oncology
;
(12)2001.
Article
Dans Chinois
| WPRIM
| ID: wpr-547175
ABSTRACT
chronic cervicitis(0%),(P=0.000).The positive rates of EPMMPRIN overexpression in metastatic lymph nodes was 54.5%(12/22),no difference was found from corresponding primary tumor(72.7%,P=0.210).But EMMPRIN overexpression in primary tumor was related to lymph node metastasis(P=0.026),no relationship was found between EMMPRIN expression and other clinical-pathological parameters.Univariate analyses revealed that EMMPRIN expression did not correlate to tumor-specific survival.In contrast,lymph vascular space invasion,deep stromal invasion and lymph node metastasis were significantlyassociated with poor prognosis.In multivariate analysis,lymph-node metastasis was the independent prognostic factor for tumor-specific survival(P=0.006;HR=0.038;95% confidence interval,0.0190.763).Conclusion:
EMMPRIN overexpression may play an important role in progression of human cervical cancer,and in the development of cervical cancer from CIN.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Étude pronostique
langue:
Chinois
Texte intégral:
China Oncology
Année:
2001
Type:
Article
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