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Comparative in vivo biodistributions of nanoparticles and polymers of ¹⁷⁷lutetium-labeled hyaluronic acids in mice during 28 days
Korean Journal of Veterinary Research ; : 105-111, 2017.
Article Dans Anglais | WPRIM | ID: wpr-54727
ABSTRACT
Hyaluronic acid (HA) has been investigated for biomedical and pharmaceutical applications. This study was conducted to determine the distributions of HA nanoparticles (NPs; size 350–400 nm) and larger HA polymers in mice at intervals after application. ¹⁷⁷Lutetium (Lu)-labeled HA-NPs or HA polymers were intravenously injected (5 mg/kg) into male ICR mice, and radioactivity levels in blood and target organs were measured from 0.25 h to 28 days post-injection. In blood, the radioactivities of HA-NPs and HA polymer peaked at 0.5 h after injection but were remarkably decreased at 2 h; subsequently, they maintained a constant level until 6 days post-injection. HA-NPs and HA polymers were observed in the liver, spleen, lung, kidney, and heart (in ascending order) but were seldom observed in other organs. After 3 days, both the HA-NP and HA polymer levels showed similar steady decreases in lung, kidney, and heart. However, in liver and spleen, the HA-NP levels tended to decrease gradually after 1 day and both were very low after 14 days, whereas the HA polymer level accumulated for 28 days. The results indicate that HA-NPs, with their faster clearance pattern, may act as a better drug delivery system than HA polymers, especially in the liver and spleen.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Polymères / Radioactivité / Rate / Systèmes de délivrance de médicaments / Nanoparticules / Coeur / Acide hyaluronique / Rein / Foie / Poumon Limites du sujet: Animaux / Humains / Mâle langue: Anglais Texte intégral: Korean Journal of Veterinary Research Année: 2017 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Polymères / Radioactivité / Rate / Systèmes de délivrance de médicaments / Nanoparticules / Coeur / Acide hyaluronique / Rein / Foie / Poumon Limites du sujet: Animaux / Humains / Mâle langue: Anglais Texte intégral: Korean Journal of Veterinary Research Année: 2017 Type: Article