Effects of Bile Acids on the Lipid Components in Human Erythrocyte Membranes / 第二军医大学学报

ABSTRACT

Fresh healthy human erythrocytes were treated by four kinds of bile acid solution (DOC, GDC, C-Na and GC-Na) at physiological and pathological concentrations of human serum level. The more hydrophobic bile acids (DOC and GDC) significantly affected lipid components of erythrocyte. membranes and morphology at concentration of 0.5 mmol/L and 1.0 mmol/L. To the extent of he-molysis DOC and GDC were more hemolytic than C-Na and GC-Na. Additionally the erthrocytes from patients with biliary obstruction were also studied. The results suggest that the more hydropho-bicity of bile acid, the more erythrocyte damage. The hydrophobicity was associated with the structure of bile acid molecules.