Effect of Perinatal Sulphamethazine Exposure on Neurotrophs Expression in Hippocampus of Offspring in Rats / 环境与健康杂志
Journal of Environment and Health
;
(12)1992.
Article
Dans Chinois
| WPRIM
| ID: wpr-547512
ABSTRACT
Objective To study the effect of perinatal exposure to sulphamethazine on the expression of neurotrophs(NGF and BDNF) in the hippocampus of offspring in rats.Methods The dams(SD rats) were fed with sulphamethazine at the doses of 50,100 and 200 mg/(kg.d) respectively from gestational day 7 to postpartum day 21.The brains of the pups aged 30 days were collected and the expression of NGF and BDNF was determined by immunohistochemistry staining.Results The expression of NGF in CA1 and CA3 of hippocampus significantly decreased in all pups of perinatal exposure to sulfamethazine(P
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Journal of Environment and Health
Année:
1992
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS