Effect of Silybin on Coxsackie B_5 Virus Infected New Born Rat Heart Cells in Culture / 第二军医大学学报

ABSTRACT

The protective effect of silybin on the micro-model of Coxsackie B5 virus infected new born rat heart cell culture was observed. After inoculation with 400TCID Coxsackie B5 virus, the cardiac enzyme s-lactic acid dehydrogenase (LDH) and glutamic oxaloacctic transaminase (GOT) were much lower in the silybin-treated groups than in those groups of untreated, but the synthesis rate of DNA was higher. Virus titer in the supernatant of cultures was detected 96 h after virus challenge. The virus titer (Lg 3. 95 TCID50) of the silybin-treated was lower than in that of untreated groups (Lg 6. 95 TCID50). These results suggest that silybin may be a useful drug in treatment of acute viral myocarditis.