Cytogenetic Studies of Peripheral Leukocytes following Surgery and Radiotherapy in Patients with Breast Carcinoma
Yonsei Medical Journal
;
: 136-139, 1977.
Article
Dans Anglais
| WPRIM
| ID: wpr-54754
ABSTRACT
Chromosome analysis were carried out on peripheral blood leukocytes of breast cancer patient during the irradiation therapy after unilateral simple mastectomy. The observations were made at intervals varying from one to 5 weeks during the therapy and one month after the completion of tile treatment. During the first and second weeks of treatment normal metaphase was noted and during the 4th and 5th weeks, there were no mitotic figures from the cell population. The chromosomal aberrations found after 3 weeks of treatment were, 11% of simple chromatid breaks, 7% of chromatid interchanges (translocations) and 8% of fragments. One month after the completion of the course of treatment showed a return of mitosis and that total chromatid breaks had decreased to 5%. Radiation effects on cell division and chromosome aberration are discussed.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs du sein
/
Aberrations des chromosomes
/
Carcinome intracanalaire non infiltrant
/
Leucocytes
/
Adulte d'âge moyen
Limites du sujet:
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Yonsei Medical Journal
Année:
1977
Type:
Article
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