Spinal fusion of lumbar intertransverse process in rabbits using two different densities of autologous marrow mesenchymal stem cells combined with ?-TCP / 中国矫形外科杂志

ABSTRACT

[Objective]To investigate the effects of two different densities of bone marrow mesenchymal stem cells (BMSCs) combined with ?-TCP on spinal fusion in rabbits.[Method]Spinal fusion surgery of lumber intertransverse process were performed using MSCs/?-TCP as a graft in two groups of rabbits (low density group versus high density group),and rate of lumbar fusion,image characteristics,bone mineralization content,bone mineralization density,bone mineralization tissue volume and rate of new bone formation were observed.[Result]Compared with the low intensity group,the rate of lumbar fusion was greatly improved in the high density group(P