Study on the apoptosis of T lymphocytes of peripheral blood in systemic lupus erythematosus(SLE) and the correlated pathogenesis / 中国免疫学杂志
Chinese Journal of Immunology
;
(12)1986.
Article
Dans Chinois
| WPRIM
| ID: wpr-548618
ABSTRACT
Objective:
To study the apoptosis of T lymphocyte subsets of peripheral blood in systemic lupus erythematosus(SLE) and the correlated pathogenesis.Methods:
The percentages of T lymphocyte subsets,the positive expression rates of Fas/FasL on T lymphocyte subsets,and the apoptosis of T lymphocyte subsets were determined by three-colorflow cytometry.The level of serum IL-10 was analyzed by ABC-ELISA.IL-10 antibody and FasL antibody were added respectively into the 48 hours' culture of 10 SLE patients' PBMCs in vitro,whose serum IL-10 significantly increased,and then,the changes of T lymphocyte subsets of SLE PBMCs were determined by three-colorflow cytometry.Results:
1) In SLE,mainly in hyperactive SLE,the apoptosis of CD4+ T lymphocytes increased significantly(P
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Etude d'étiologie
langue:
Chinois
Texte intégral:
Chinese Journal of Immunology
Année:
1986
Type:
Article
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