Effect and mechanism of Ghrelin on the colonic motility of diabetic mice / 中国现代普通外科进展
Chinese Journal of Current Advances in General Surgery
;
(4)2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-548679
ABSTRACT
Objective:
To investigate colonic motility effect and mechanism of Ghrelin in diabetic mice.Methods:
In vivo,the effects of Ghrelin(50,100,200 ?g/kg)on colonic transit of diabetic mice were measured by charcoal suspension pushing test.The effects of Atropine,N?-nitro-L-arginine methylester hydrochloride(L-NAME)and D-Lys3-GHRP-6(GHS-R antagonist)on the colonic transit of Ghrelin(200 ?g/kg)were also investigated.In vitro,the effects of Ghrelin on spontaneous contraction of proximal colonic circular muscle strips of diabetic mice were studied.Results:
Ghrelin accelerated colonic transit of diabetic mice with significant dose-response relationship(P
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Current Advances in General Surgery
Année:
2004
Type:
Article
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