Gynura procumbens extract improves insulin sensitivity and suppresses hepatic gluconeogenesis in C57BL/KsJ-db/db mice
Nutrition Research and Practice
;
: 507-515, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-54926
ABSTRACT
BACKGROUND/OBJECTIVES:
This study was designed to investigate whether Gynura procumbens extract (GPE) can improve insulin sensitivity and suppress hepatic glucose production in an animal model of type 2 diabetes. MATERIALS/METHODS:
C57BL/Ksj-db/db mice were divided into 3 groups, a regular diet (control), GPE, and rosiglitazone groups (0.005 g/100 g diet) and fed for 6 weeks.RESULTS:
Mice supplemented with GPE showed significantly lower blood levels of glucose and glycosylated hemoglobin than diabetic control mice. Glucose and insulin tolerance test also showed the positive effect of GPE on increasing insulin sensitivity. The homeostatic index of insulin resistance was significantly lower in mice supplemented with GPE than in the diabetic control mice. In the skeletal muscle, the expression of phosphorylated AMP-activated protein kinase, pAkt substrate of 160 kDa, and PM-glucose transporter type 4 increased in mice supplemented with GPE when compared to that of the diabetic control mice. GPE also decreased the expression of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase in the liver.CONCLUSIONS:
These findings demonstrate that GPE might improve insulin sensitivity and inhibit gluconeogenesis in the liver.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phosphoénolpyruvate
/
Hémoglobine glyquée
/
Insulinorésistance
/
Glucosephosphatase
/
Muscles squelettiques
/
Modèles animaux
/
Régime alimentaire
/
AMP-Activated Protein Kinases
/
Néoglucogenèse
/
Glucose
Type d'étude:
Etude diagnostique
/
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Nutrition Research and Practice
Année:
2016
Type:
Article
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