Mechanism of Erythrocyte Damage after Burn Injury in Rats; Relationship between Lipid Peroxides, Vitamin E and Hemolysis / 第三军医大学学报

ABSTRACT

It was found that a large amount of malonyldialdehyde ( MDA ) was formed in the burnt skin after 20% TBSA full thickness burns was inflicted to rats. The re were 2 peaks of the increase of MDA on the 2nd and 7th day postburn in the skin respectively. The content of MDA in the plasma and erythrocytes also increased and reached the peak on the 3rd day after injury. The content of vitamin E in the plasma and erythrocytes decreased rapidly from the 2nd day postburn and reached the lowest point on the 3rd day- Hemolysis was found to be the severest on the 3rd day postbarn. After the relationship between the MDA levels in the burnt skin, plasma, and erythrocytes, the vitamin E levels in the plasma and ery-throcyles, and the severity of hemolysis was analyzed, it was found that there was different correlation rale between these parameters in different time-phases, but the general rule was that when MDA increased in the burnt skin, plasma and erythrocytes, vitamin E decreased in the plasma and erythrocytes and hemolysis became more severe. On the basis of these findings, the mechanism of erythrocyte damage after burn injury was discussed.