DIAGNOSTIC VALUES OF ASSAY FOR ABNORMAL PROTHROMBIN IN PATIENTS WITH PRIMARY HEPATOCELLULAR CARCINOMA / 第二军医大学学报

ABSTRACT

In this study, we determined plasma abnormal prothrombin concentrations in 98 patients with histologically-proved primary hepatoceliular carcinoma (HCC) and 181 patients with other diseases using a radio-rocket electrophoresis autography. Out of 98 patients with HCC, 68 had abnormal prothrombin levels above or equal to 250 ?g/L and the positively was 69.4%, which was much higher than that in other groups. Abnormal prothrombin levels correlated poorly with those of alpha-fetoprotein (AFP)(r = 0.317), The positiveties of abnormal prothrombin level in HCC with low AFP level and with AFP negative were 63.8% and 65.5%. respectively. When used in combination, both tests could identify 84.7% of patients with HCC and 84.2% of patients with small HCC, respectively. The results show that the assay for plasma abnormal prothrombin may be useful in diagnosing low AFP-producing or AFP negative HCC, and also in discriminating HCC from chronic liver diseases and benign tumors of liver.