Study on the Prophylactic Effect of Folic acid on the Toxicity of Nitroquine / 第三军医大学学报

ABSTRACT

232 mice were utilized in this study. ( 1 ) After administration of nitroquine 570mg/kg?1 po, the mice were given with normal saline(NS)and folic acid(NF,8 nag/kg x l im)in two subgroups respectively. 96h later, decrease in number and shorter in length of intestinal villi, and necrosis of epithelial cells, especially the crypt cells showed markedly in NS group, but much mild in NF group. ( 2 ) The DNA contents in the tissue of the small intestine showed decrease after nitroquine administration, & markedly in the larger dose and as the time going on. The values of cpm after the[3H] TdR incorporation into DNA wete much higher in NF group than in the NS group. The results suggest that the DNA synthesis in small intestine is promoted by folic acid, so that it is advantage for the repairing of damaged intestinal mucosa.