EFFECTS OF VERAPAMIL ON DNA, RNA AND PROTEIN SYNTHESIS OF HUMAN FIBROBLASTS / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)1987.
Article
de Zh
| WPRIM
| ID: wpr-550154
Bibliothèque responsable:
WPRO
ABSTRACT
In order to investigate the action of calcium antagonists on metabolism of intracellular macromolecules, The authors observed the effects of verapamil on the incor-poration of 〔 3H 〕 TdR, 〔 3H 〕 UR and 〔 3H 〕 Leu into human fibroblasts. The inhibitory effects on DNA and RNA synthesis were concentration dependent, ID50 was l2.3mg/L and 22mg/L, respectively. The inhibitory effect on the synthesis of protein was weak.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Pharmacological Bulletin
Année:
1987
Type:
Article