THE EFFECTS OF 10-HDA ON IMMUNE FUNCTION OF MICE / 中国药理学通报

ABSTRACT

We observed the effects of 10-hydroxy-decenoic acid ( 10-HDA ) extracted from royal jelly on the immune function of mice. It was showed that after ig or ip administration of 10-HDA, the phagocytosis of mouse peritoneal macrophages to cock red blood cells was inhibited. Although the count of lymphocytes in mouse peripheral blood was not changed after administration of 10-HDA, the in vivo lymphocyte tran- sformation of mice induced by PHA was significantly enhanced. It was also showed in our experiment that after 7d administration of 10-HDA, the content of vitamin C in adrenal glands of mice was significantly increased ( same as after ACTH administration ) . The results of our experiments indicated that 10-HDA has the inhibiting effect on immune function of mice and this effect may be related to enhancing adrenal cortex function.